THURSDAY 2 AUGUST 2001

IBT MAKES INVESTMENT OF $7.5 MILLION IN NEWLY MERGED MICROCIDE
PHARMACEUTICALS AND THE ALTHEXIS COMPANY

2 August 2001, London, UK: International Biotechnology Trust Plc. (LSE: IBT) today announced that it has committed to invest $7.5 million (£5.3 million) in the newly combined operations of Microcide Pharmaceuticals, Inc. (NASDAQ: MCDE) and the Althexis Company, Inc. On Monday 30th July Microcide and Althexis announced the signing of a definitive agreement to merge their businesses in a stock-for-stock exchange; completion of the merger and private placement remains subject to MCDE shareholder approval.

The total financing round raised $60 million (£42 million), and in addition to IBT, investors included Prospect Venture Partners, New Enterprise Associates and Schroder Ventures' International Life Sciences Fund II.

Kate Bingham, General Partner of Schroder Venture Life Sciences, investment advisors to IBT, who will join the Board of the newly merged company, commented on the investment:

"We have been seeking quality investment opportunities for IBT following our appointment as investment advisors at the end of last year. This is the largest investment we have made this year for IBT and it will be one of its top ten. This is also the second time that the Schroder Venture Life Sciences team has backed Mark Skaletsky who will be chairman and CEO of the newly merged company." Mark Skaletsky previously built and sold Geltex to Genzyme.

The merger of Microcide Pharmaceuticals and the Althexis Company will unite Microcide's discovery platforms, including its VALID Microbial Genomics technologies, with Althexis' proprietary target validation system, known as ACTT. It will also accelerate Microcide's multiple drug development programs in infectious disease by applying Althexis' Structure-Based Design (SBDD) technology to lead optimisation.

The $60 million in private equity funding is being provided in a private placement of Microcide convertible redeemable preferred stock.

The preferred stock is convertible into shares of Microcide common stock at a fixed exchange ratio of $3.00 per share, which represents a 24% discount from the 20-day average closing price of Microcide as of July 19 2001, the date on which the Company authorized the offering. Preferred shares converted into common stock will be registered by a Form S-3 filing, and will be subject to certain lockup provisions for up to 9 months after closing. Under the terms of the merger agreement, as unanimously approved by the Boards of Directors of both Althexis and Microcide, Microcide will issue approximately 5.3 million shares of common stock for all outstanding shares of Althexis, and will assume the outstanding options of Althexis. All but approximately 400,000 of the newly issued Microcide shares to Althexis shareholders will be subject to certain restrictions on resale for one year from closing.
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For further information, please contact:

International Biotechnology Trust
Andrew Barker
Tel: +44 (0) 20 7658 3206
Fax: +44 (0) 20 7658 2422

Schroder Ventures Life Sciences
Jodie Van Elst
Tel: +44 (0)20 7421 7070
Fax: +44 (0)20 7421 7077
Email: jodie.vanelst@svlifesciences.com

GCI Financial
Emily Morris/Katherine Harris
Tel: +44 (0)20 7398 0800
Fax: +44 (0)20 7398 0888
Email: emorris@gcifinancial.com